推荐产品
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥95% (SDS-PAGE)
形狀
lyophilized powder
分子量
16 kDa (including a 31 amino-acid spacer and 6-His tag)
包裝
pkg of 0.1 mg
技術
cell culture | mammalian: suitable
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... MSTN(2660)
應用
Use recombinant myostatin to study its mechanisms of action in vitro.
生化／生理作用
Myostatin is a 25 KDa, homodimer, that acts on muscle to induce SMAD family transcription factors such as SMAD2 and SMAD3. It inhibits the differentiation of myoblasts into mature muscle fibers. Positive control for myostatin in Western blots and ELISA.
Positive control for myostatin in Western blots and ELISA.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Karima Relizani et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(8), 1423-1433 (2014-05-28)
Myostatin regulates skeletal muscle size via the activin receptor IIB (ActRIIB). However, its effect on muscle energy metabolism and energy-dependent muscle function remains largely unexplored. This question needs to be solved urgently since various therapies for neuromuscular diseases based on
H Takahashi et al.
Domestic animal endocrinology, 48, 62-68 (2014-06-08)
The purpose of this study was to determine whether myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Plasma concentrations of glucose were lower in DM cattle
R E Ferrell et al.
Genomics, 62(2), 203-207 (1999-12-28)
Myostatin is a recently identified member of the transforming growth factor-beta family of regulatory factors, also known as growth and differentiation factor 8 (GDF8). The nucleotide sequence of human myostatin was determined in 40 individuals. The invariant promoter contains a
Qiang Zhang et al.
The FEBS journal, 277(2), 466-476 (2009-12-18)
The ubiquitin ligase RING finger protein 13 gene (RNF13) was first identified in a screen for genes whose expression is regulated by myostatin in chicken fetal myoblasts. In this study, we demonstrate that the RNF13 gene is broadly expressed in
Yutaka Ohsawa et al.
PloS one, 10(7), e0133713-e0133713 (2015-08-01)
Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating complex. However, which region of the myostatin prodomain is
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