跳转至内容
Merck

I6125

Sigma-Aldrich

碘乙酰胺

≥99% (NMR), crystalline

别名:

α-Iodoacetamide, 2-Iodoacetamide

登录查看公司和协议定价


About This Item

线性分子式:
ICH2CONH2
CAS号:
分子量:
184.96
Beilstein:
1739080
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

化驗

≥99% (NMR)

形狀

crystalline

mp

92-95 °C (lit.)

溶解度

H2O: soluble 0.5 M, clear, colorless

儲存溫度

2-8°C

SMILES 字串

NC(=O)CI

InChI

1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI 密鑰

PGLTVOMIXTUURA-UHFFFAOYSA-N

正在寻找类似产品? 访问 产品对比指南

應用


  • 一种基于使用碘乙酰胺和丙烯酰胺对半胱氨酸进行差异烷基化的蛋白质质谱定量策略。:本研究提出了一种新的质谱方法,通过用碘乙酰胺和丙烯酰胺对半胱氨酸进行差异烷基化来定量蛋白质,从而提高复杂样品中蛋白质定量的准确性。(Virág et al., 2024)。

  • 海带多糖通过调节5-HT(3)受体和肠道微生物群改善碘乙酰胺诱导的功能性消化不良。:研究表明,海带多糖可以通过调节5-HT(3)受体和改变肠道微生物群组成来减轻碘乙酰胺诱导的功能性消化不良,从而提供潜在的治疗效果。(Liu et al., 2024)。

  • 黑色素瘤细胞的氧化还原蛋白质组学:优化方案。:本文描述了一种使用碘乙酰胺优化的氧化还原蛋白质组学方案,该方案有助于识别黑色素瘤细胞中的氧化还原敏感蛋白,有助于了解癌症中的氧化还原调节。(Cunha et al., 2024)。

  • 通过基于竞争活性的蛋白质分析策略探索顺铂在HeLa细胞中的分子靶点。:本研究使用碘乙酰胺进行基于竞争活性的蛋白质分析,确定了顺铂在HeLa细胞中的分子靶点,进一步阐释了药物机制。(Chen et al., 2024)。

  • 4-硫尿苷向胞苷碱转化反应的进展和比较。:本研究比较了涉及4-硫尿苷和胞苷的碱基转化反应,其中碘乙酰胺在反应机制中起着至关重要的作用,为核苷酸化学的进步添砖加瓦。(Ohashi et al., 2024)。

生化/生理作用

碘乙酰胺在肽测序中胱氨酸残基的烷基化试剂。它是活性位点上含有胱氨酸的酶的的一种不可逆抑制剂。它与组氨酸残基的反应速度要慢得多,但这种活性是核糖核酸酶抑制的原因。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Chiara Francavilla et al.
The Journal of cell biology, 187(7), 1101-1116 (2009-12-30)
Neural cell adhesion molecule (NCAM) associates with fibroblast growth factor (FGF) receptor-1 (FGFR1). However, the biological significance of this interaction remains largely elusive. In this study, we show that NCAM induces a specific, FGFR1-mediated cellular response that is remarkably different
Mirko Zaffagnini et al.
Antioxidants & redox signaling, 16(1), 17-32 (2011-06-29)
Cysteines (Cys) made acidic by the protein environment are generally sensitive to pro-oxidant molecules. Glutathionylation is a post-translational modification that can occur by spontaneous reaction of reduced glutathione (GSH) with oxidized Cys as sulfenic acids (-SOH). The reverse reaction (deglutathionylation)
Valentina R Minciacchi et al.
Oncotarget, 6(13), 11327-11341 (2015-04-11)
Large oncosomes (LO) are atypically large (1-10 µm diameter) cancer-derived extracellular vesicles (EVs), originating from the shedding of membrane blebs and associated with advanced disease. We report that 25% of the proteins, identified by a quantitative proteomics analysis, are differentially
Gabriela Venturini et al.
American journal of physiology. Cell physiology, 317(2), C326-C338 (2019-05-09)
Atherosclerotic plaque development is closely associated with the hemodynamic forces applied to endothelial cells (ECs). Among these, shear stress (SS) plays a key role in disease development since changes in flow intensity and direction could stimulate an atheroprone or atheroprotective
Elena B Lugli et al.
Arthritis research & therapy, 17, 9-9 (2015-01-21)
Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic. To investigate this mechanism, we examined human lung tissue from 40 subjects with defined smoking status, with or without

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门