所有图片(1)
About This Item
经验公式（希尔记法）:
C27H46O2
CAS号:
分子量:
402.65
MDL號碼:
分類程式碼代碼:
12352211
eCl@ss:
39023139
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98%
形狀
powder
運輸包裝
ambient
儲存溫度
room temp
SMILES 字串
[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])[C@H](C)[C@H](O)CCC(C)C
InChI
1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
InChI 密鑰
RZPAXNJLEKLXNO-GFKLAVDKSA-N
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應用
使用22（R）-羟基胆固醇处理牛主动脉内皮细胞以研究其对自由基产生的影响 以及用于与脂肪酸代谢有关的研究。
生化／生理作用
22（R）-羟基胆固醇是从胆固醇合成孕烯醇酮途径中的一种中间体。据报道它具有神经保护特性并可保护神经元免受β-淀粉样蛋白诱导的细胞死亡。 22(R)-羟基胆固醇可作为肝X受体的配体，该受体可充当甾醇浓度的传感器并调节脂肪酸代谢。
準備報告
22（R）-羟基胆固醇在氯仿中可产生澄清无色的溶液。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
A Chawla et al.
Science (New York, N.Y.), 294(5548), 1866-1870 (2001-12-01)
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands that bind to receptors in the nucleus. To become biologically active, these lipids must first be absorbed
Lourdes Cruz-Garcia et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 160(2), 125-136 (2011-06-04)
The liver X receptor (LXR) has recently been described in salmonids. In mammals, this receptor is already known as a transcriptional factor that regulates diverse aspects of cholesterol, fatty acid and carbohydrate metabolism in various tissues, including muscle. Here we
Cynthia Hong et al.
Journal of lipid research, 52(3), 531-539 (2010-12-29)
Ligand activation of liver X receptors (LXRs) has been shown to impact both lipid metabolism and inflammation. One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects. Here, we describe an LXR gain-of-function
Linara Gabitova et al.
Cell reports, 12(11), 1927-1938 (2015-09-08)
Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor receptor (EGFR) or RAS increases the demand for cholesterol, suggesting a possibility for metabolic
Nina Hallmark et al.
Environmental health perspectives, 115(3), 390-396 (2007-04-14)
Certain phthalates can impair Leydig cell distribution and steroidogenesis in the fetal rat in utero, but it is unknown whether similar effects might occur in the human. Our aim in this study was to investigate the effects of di(n-butyl) phthalate
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