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About This Item
经验公式（希尔记法）:
C35H52O4
CAS号:
分子量:
536.78
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥85% (HPLC)
形狀
solution
儲存溫度
−20°C
SMILES 字串
CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O
InChI
1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChI 密鑰
IWBJJCOKGLUQIZ-HQKKAZOISA-N
一般說明
贯叶金丝桃素是圣约翰′草的一种间苯三酚成分，同时也是一种孕烷 X 受体配体。
應用
贯叶金丝桃素可用于：
- 作为参考标准品用于制定高效液相色谱 (HPLC) 分析的校准曲线
- 测试其对小鼠他胚胎细胞的细胞毒性作用和诱导细胞凋亡作用
- 作为猪脑毛细血管内皮细胞孕烷X受体 (PXR) 用于传递检测
生化／生理作用
贯叶金丝桃素是一种活性抗抑郁剂和细胞色素P450 3A4 (CYP3A) 抑制剂。它可诱导抗氧化和抗细菌活性。贯叶金丝桃素还具有胚胎毒性并抑制肿瘤增生。它可有效抑制多巴胺、血清素和去甲肾上腺素。
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Rajanikanth Madabushi et al.
European journal of clinical pharmacology, 62(3), 225-233 (2006-02-16)
Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John's wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with
Martina C Meinke et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(2), 346-350 (2012-03-21)
Hyperforin, a major constituent of St. John's Wort (Hypericum perforatum, HP), provides anti-inflammatory, anti-tumor, and anti-bacterial properties. Previous studies have shown anti-oxidative properties of St. John's Wort extracts; however, its free radical scavenging activity in skin cells or skin has
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures
Komoroski BJ, et al.
Drug Metabolism and Disposition, 32(5), 512-518 (2004)
Determination of hypericin and hyperforin content in selected Jordanian Hypericum species
Tawaha K, et al.
Industrial Crops and Products, 32(3), 241-245 (2010)
Faten Merhi et al.
PloS one, 6(10), e25963-e25963 (2011-10-15)
The natural phloroglucinol hyperforin HF displays anti-inflammatory and anti-tumoral properties of potential pharmacological interest. Acute myeloid leukemia (AML) cells abnormally proliferate and escape apoptosis. Herein, the effects and mechanisms of purified HF on AML cell dysfunction were investigated in AML
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