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重組細胞
expressed in baculovirus infected insect cells
品質等級
形狀
buffered aqueous solution
分子量
55-60 kDa
包裝
vial of 2.5 mg
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... FMO3(2328)
一般說明
含黄素单加氧酶-3 (FMO3)是含黄素单加氧酶(FMO)家族中的一员。它在人类肝脏中高度表达。
應用
FMO3是主要的人肝脏形式。
生化／生理作用
含黄素单加氧酶-3 (FMO3)可促进几种药物、化学品和外源性物质的氧化。人FMO3也参与了由三甲胺(TMA)合成三甲胺(TMAO)的N-氧化物。FMO3基因突变与臭鱼症或鱼腥症有关。FMO3基因的缺失可导致血浆TMAO水平降低，从而降低动脉粥样硬化和血栓形成的风险。
外觀
溶于100 mM磷酸钾缓冲液，pH 7.4的溶液
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
W Zhu et al.
Journal of thrombosis and haemostasis : JTH, 16(9), 1857-1872 (2018-07-08)
Essentials Microbe-dependent production of trimethylamine N-oxide (TMAO) contributes to thrombosis risk. The impact of host flavin monooxygenase 3 (FMO3) modulation on platelet function is unknown. Genetic manipulation of FMO3 in mice alters systemic TMAO levels and thrombosis potential. Genetic manipulation
Chongliang Gao et al.
Scientific reports, 7(1), 14668-14668 (2017-11-09)
Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies
Irfan M Hisamuddin et al.
Pharmacogenomics, 8(6), 635-643 (2007-06-15)
Flavin-containing monooxygenase 3 (FMO3) is a hepatic microsomal enzyme that oxidizes a host of drugs, xenobiotics and other chemicals. Numerous variants in the gene encoding FMO3 have been identified, some of which result in altered enzymatic activity and, consequently, altered
Robert R Reddy et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2239-2245 (2010-09-03)
The flavin-containing monooxygenase (FMO) family of enzymes oxygenates nucleophilic xenobiotics and endogenous substances. Human FMO3 and FMO5 are the predominant FMO forms in adult liver. These enzymes are naturally membrane-bound, and recombinant proteins are commercially available as microsomal preparations from
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