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Merck
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F2552

Sigma-Aldrich

福美斯坦

solid

别名:

4-Hydroxyandrost-4-ene-3,17-dione, CGP-32349

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About This Item

经验公式（希尔记法）:
C19H26O3
CAS号:
566-48-3
分子量:
302.41
MDL编号:
MFCD00057814
UNSPSC代码:
12352204
PubChem化学物质编号:
24894827
NACRES:
NA.25

生物来源

synthetic (organic)

方案

≥98% (HPLC)

表单

solid

技术

HPLC: suitable
gas chromatography (GC): suitable

溶解性

chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

应用

forensics and toxicology
veterinary

储存温度

2-8°C

SMILES字符串

C[C@]12CC[C@H]3[C@@H](CCC4=C(O)C(=O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

InChI key

OSVMTWJCGUFAOD-KZQROQTASA-N

基因信息

human ... CYP19A1(1588)

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相关类别

生化/生理作用

Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCS2320
MKCN7345
MKCF5599
MKCC3385
MKBX1177V

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Davide Mauri et al.
Journal of the National Cancer Institute, 98(18), 1285-1291 (2006-09-21)
Aromatase inhibitors and inactivators have been extensively tested in patients with advanced breast cancer, but it is unclear whether they offer any survival benefits compared with standard hormonal treatment with tamoxifen or progestagens. We performed a meta-analysis of randomized controlled
P E Lønning et al.
The Journal of steroid biochemistry and molecular biology, 77(1), 39-47 (2001-05-19)
Formestane (Lentaron(R), 4-hydroxyandrostenedione) is a steroidal aromatase inhibitor used for treatment of advanced breast cancer. Clinically, it is administered as a depot form once fortnightly by intramuscular (i.m.) injection. To investigate the pharmacokinetics, bioavailability and metabolism of the drug, seven
Jie Wang et al.
Frontiers in systems neuroscience, 14, 546531-546531 (2020-10-06)
In rodents, the period of increased vulnerability to the developmental effects of general anesthetics coincides with the period of age-specific organizing (masculinizing) effects of the major female sex hormone 17β-estradiol (E2) in the male brain and excitatory GABA type A
Adam T Cawley et al.
Rapid communications in mass spectrometry : RCM, 22(24), 4147-4157 (2008-11-26)
Studies have shown that the administration of androstenedione (ADIONE) significantly increases the urinary ratio of testosterone glucuronide to epitestosterone glucuronide (T/E) - measured by gas chromatography/mass spectrometry (GC/MS) - in subjects with a normal ( approximately 1) or naturally high
Lucía Martínez-Mota et al.
Pharmacology, biochemistry, and behavior, 88(3), 332-340 (2007-10-05)
In male rats, the antidepressant-like effect of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST) is reduced by orchidectomy and partially restored by testosterone (T). It is unknown if this modulation of T is produced by its
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