推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 50 kDa
种属反应性
rat, human, mouse
包装
antibody small pack of 25 μL
浓度
~1 mg/mL
技术
immunoprecipitation (IP): 1-2 μg using HeLa cell lysates.
western blot: 0.5-1 μg/mL using 3T3 or Rat1 cell extracts.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ETF1(2107)
mouse ... Etf1(225363)
rat ... Etf1(307503)
一般描述
Eukaryotic translation termination factor 1 (eRF1) is a protein encoded by the ETF1 gene in humans. It belongs to eRF1 family and the amino-acid sequence is highly conserved.
应用
Anti-eRF1 antibody produced in rabbit has been used in western blotting and immunoprecipitation.
生化/生理作用
Eukaryotic translation termination factor 1 (eRF1) proteins are directly implicated in the termination of translation in eukaryotes. It plays an important role in the termination of protein synthesis, which is performed by three domains (N, M and C) of eRF1. Rearrangement in eRF1 leads to N-domain accommodation into the ribosomal A site.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division
Petsch K, et al.
Plant Physiology, 139(1), 115-126 (2005)
L Frolova et al.
Nature, 372(6507), 701-703 (1994-12-15)
The termination of protein synthesis in ribosomes is governed by termination (stop) codons in messenger RNAs and by polypeptide chain release factors (RFs). Although the primary structure of prokaryotic RFs and yeast mitochrondrial RF is established, that of the only
Toshiaki Shigeoka et al.
Nucleic acids research, 40(14), 6887-6897 (2012-05-05)
Upf1 is a highly conserved RNA helicase essential for nonsense-mediated mRNA decay (NMD), an mRNA quality-control mechanism that degrades aberrant mRNAs harboring premature termination codons (PTCs). For the activation of NMD, UPF1 interacts first with a translation-terminating ribosome and then
Leo E Wong et al.
Nucleic acids research, 40(12), 5751-5765 (2012-03-03)
Translation termination in eukaryotes is catalyzed by two release factors eRF1 and eRF3 in a cooperative manner. The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. By solving the solution
Polina Kryuchkova et al.
Nucleic acids research, 41(8), 4573-4586 (2013-02-26)
Release factor eRF1 plays a key role in the termination of protein synthesis in eukaryotes. The eRF1 consists of three domains (N, M and C) that perform unique roles in termination. Previous studies of eRF1 point mutants and standard/variant code
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