E3888

[D-Pen^2,5]-Enkephalin hydrate

≥95% (HPLC)

• 别名: DPDPE
• 经验公式（希尔记法）: C₃₀H₃₉N₅O₇S₂ · xH₂O
• 分子量: 645.79 (anhydrous basis)
• MDL號碼: MFCD00076430
• 分類程式碼代碼: 12352209
• PubChem物質ID: 329799055
• NACRES: NA.32

属性

• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 儲存溫度: −20°C
• SMILES 字串: CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H]1C(O)=O
• InChI: 1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
• InChI 密鑰: MCMMCRYPQBNCPH-WMIMKTLMSA-N

说明

Amino Acid Sequence

Tyr-Pen-Gly-Phe-Pen [Disulfide Bridge: 2-5]

一般說明

[D-Pen^2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist. Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.

應用

[D-Pen^2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents. It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).

生化／生理作用

Antinociceptive activity mediated through the δ₁ receptor while the modulatory activity is mediated through the δ₂ receptor. Tritiated [D-Pen^2,5]-enkephalin is used as a δ₁ ligand.

其他說明

Lyophilized from 0.1% TFA in H2O

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)