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化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D +125 to +135°, c = 1 in methanol
儲存條件
desiccated
顏色
white
溶解度
DMSO: ≥20 mg/mL
起源
Eli Lilly
儲存溫度
room temp
SMILES 字串
Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3
InChI
1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1
InChI 密鑰
IHWDIQRWYNMKFM-BDQAORGHSA-N
基因資訊
human ... SLC6A4(6532)
一般說明
达泊西汀（(+)-(S)-N,N-二甲基-(α)-[2(1萘氧基)乙基]-苯甲胺盐酸盐）的结构类似于氟西汀。
生化／生理作用
有效的选择性5-羟色胺再摄取抑制剂（SSRI）；用于治疗早泄
达泊西汀可阻断重组Kv4.3电压门控钾通道。已确认为安全的治疗药物。
特點和優勢
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Stanley E Althof et al.
The journal of sexual medicine, 7(6), 2243-2252 (2010-04-07)
The Clinical Global Impression of Change (CGIC) measures have high utility in clinical practice. However, it is unknown whether the CGIC is valued for assessing premature ejaculation (PE) symptoms and/or the relationship between CGIC and other validated PE patient-reported measures.
Tae Kon Kim et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 926, 42-46 (2013-04-02)
In this study, we describe and validate a rapid and sensitive method for quantitation of dapoxetine in rat plasma by using ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS). Plasma samples were prepared by protein precipitation with acetonitrile, and sildenafil
Pierre Clément et al.
The journal of sexual medicine, 9(10), 2562-2573 (2012-08-22)
A brain network specifically activated when ejaculation occurs has been described in rats. Increasing serotonin (5-hydroxytryptamine [5-HT]) tone impairs ejaculation and chronic 5-HT selective serotonin reuptake inhibitors (SSRIs) are known to inhibit ejaculation. However, efficacy of acute treatment with SSRI
Hartmut Porst et al.
The journal of sexual medicine, 7(6), 2231-2242 (2010-04-24)
Premature ejaculation (PE) is classified as an acquired or lifelong condition but data on baseline characteristics and response to treatment of men with acquired or lifelong PE and mild erectile dysfunction (ED) or normal erectile function (EF) is limited. To
Dapoxetine: a new option in the medical management of premature ejaculation
McMahon CG
Therapeutic Advances in Urology, 4(5), 233-251 (2012)
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