所有图片(3)
About This Item
经验公式（希尔记法）:
C18H33ClN2O5S · HCl
CAS号:
分子量:
461.44
Beilstein:
4070786
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
表单
powder or crystals
杂质
≤13%
溶解性
H2O: 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
InChI
1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1
InChI key
AUODDLQVRAJAJM-XJQDNNTCSA-N
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一般描述
化学结构：大环内酯
应用
克林霉素用于研究细菌感染，例如 B 组链球菌病、细菌抗性和血浆蛋白结合。
用于研究细菌蛋白质合成。
生化/生理作用
克林霉素是一种由林可霉素制备的半合成林可酰胺类抗生素。 它通过与 50S 核糖体亚基的 23S rRNA 组分的氢键相互作用，抑制细菌蛋白质合成，从而诱导肽基-t-RNA 复合物的解离。它具有抗革兰氏阳性球菌的抗菌活性，以及抗弓形虫的抗原虫活性。
克林霉素盐酸盐对厌氧菌非常有效。
其他说明
林可酰胺类的抗菌和抗原生动物抗生素。
保持容器密闭，置于干燥通风处。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Lact. - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Anouk E Muller et al.
Antimicrobial agents and chemotherapy, 54(5), 2175-2181 (2010-02-24)
The study presented here was performed to determine the pharmacokinetics of intravenously administered clindamycin in pregnant women. Seven pregnant women treated with clindamycin were recruited. Maternal blood and arterial and venous umbilical cord blood samples were obtained. Maternal clindamycin concentrations
J Spízek et al.
Applied microbiology and biotechnology, 64(4), 455-464 (2004-02-06)
Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may even be bactericidal at the higher concentrations that can be reached in vivo. Clindamycin is usually more
Nasim Farahmand et al.
Microorganisms, 9(8) (2021-08-28)
A selection of 36 commercial probiotic fermented dairy products from UK and Europe markets were evaluated for the numbers, types, and viability of Lactobacillus strains against the stated information on their packages. A comparative study was carried out on selectivity
A Burian et al.
The Journal of antimicrobial chemotherapy, 66(1), 134-137 (2010-11-04)
although plasma protein binding (PPB) is accepted to be an essential factor in reducing antimicrobial activity, little is known about the underlying mechanisms. One possibility includes impaired penetration of an antimicrobial into bacterial cells in the presence of PPB. As
Sonja Löfmark et al.
The Journal of antimicrobial chemotherapy, 58(6), 1160-1167 (2006-10-19)
The aim was to study the long-term consequences of 1 week clindamycin administration regarding selection and persistence of resistance, resistance determinants and diversity of the Bacteroides spp. in the intestinal microflora. A total of 1306 Bacteroides isolates were collected from
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