推荐产品
生物来源
human leucocytes
质量水平
表单
lyophilized powder
比活
≥60 units/mg protein (Bradford)
分子量
23-30 kDa
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... CTSG(1511)
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一般描述
Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.
应用
Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.
生化/生理作用
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.
Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
单位定义
One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.
外形
Lyophilized from 0.5 M pyridinium acetate, pH 5.3.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
其他客户在看
P I Bird
Immunology and cell biology, 77(1), 47-57 (1999-04-02)
Caspase activation and apoptosis can be initiated by the introduction of serine proteinases into the cytoplasm of a cell. Cytotoxic lymphocytes have evolved at least one serine proteinase with specific pro-apoptotic activity (granzyme B), as well as the mechanisms to
Cell surface cathepsin G activity differs between human natural killer cell subsets
Penczek A, et al.
Immunology Letters, 179, 80-84 (2016)
The role and mechanism of cathepsin G in dermatomyositis
Gao S, et al.
Biomedicine and Pharmacotherapy, 94, 697-704 (2017)
Protein Degradation in Health and Disease (2009)
Delivery and therapeutic potential of human granzyme B
Kurschus FC and Jenne DE
Immunological Reviews, 235(1), 159-171 (2010)
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