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product name
2,3-丁二酮一肟, ≥98%
化驗
≥98%
形狀
powder
bp
185-186 °C (lit.)
mp
75-78 °C (lit.)
SMILES 字串
CC(=O)\C(C)=N\O
InChI
1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+
InChI 密鑰
FSEUPUDHEBLWJY-HWKANZROSA-N
基因資訊
human ... KCNB1(3745)
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應用
2,3-丁二酮一肟可以用于：
- 单-分子肌球蛋白v活性测定
- 转基因动物成像麻醉
- 降低肌肉纤维紧张张力
- 小鼠心肌细胞培养基成分
生化／生理作用
2,3-丁二酮一肟是ATP-敏感K+和Ca2+通道抑制剂。
DRK1是一种延迟整流 (Kv2.1)克隆K+ 通道，来自大鼠大脑，和基于蛋白质激酶磷酸化有相同位点，可能与官能化调节磷酸化有关。 2,3-丁二酮一肟（BDM）化学性地从许多蛋白质中移除磷酸基团。在蟾蜍卵母细胞DRK1 CRNA表达后研究它对于DRK1通道的行为。在双电极电压钳实验中，将2,3-丁二酮一肟用于浴槽抑制DRK1电流(ki = 16.6 mM, H = 0.96)速度快，而且可逆，时间过程和浴槽内溶液改变时间过程相似。DRK1电流在所有电位被抑制；电流活化，钝化和失活的时间过程没有被2,3-丁二酮一肟影响。在内面向外式膜片钳实验中，在缺少再磷酸化底物时，在细胞表面使用2,3-丁二酮一肟同样也会快速地抑制通道活性，而且可逆 (ki = 10.7 mM, H = 1.01)。这些结果和磷酸酶效应不一致，因为磷酸酶效应应该在无细胞，无ATP的膜片中不可逆的。相反，结果显示2,3-丁二酮一肟能够从膜里或膜外直接抑制DRK1通道。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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