所有图片(2)
About This Item
经验公式（希尔记法）:
C16H29N7O8
CAS号:
分子量:
447.44
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
生物来源
synthetic (organic)
方案
≥95% (HPLC)
表单
powder
储存温度
−20°C
SMILES字符串
CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O
InChI
1S/C16H29N7O8.C2H4O2/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31;1-2(3)4/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20);1H3,(H,3,4)/t8-,9-,10-;/m0./s1
InChI key
SALKOFBHHIHLSW-PUBMXKGKSA-N
基因信息
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
Amino Acid Sequence
Arg-Gly-Glu-Ser
应用
Arg-Gly-Glu-Ser acetate salt has been used:
- as an integrin blocking peptide to study its effects on ciliary neurotrophic factor (CNTF) regulation in astroglioma cells
- as a control peptide to study its effects on the binding of patient IgG to integrin αvβ6
- as an integrin inhibitor peptide to study its effects on cell adhesion in Capsaspora owczarzaki cells
生化/生理作用
Arg-Gly-Glu-Ser peptide acts as an integrin-blocking peptide.
Inhibitor of platelet aggregation
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Seong Su Kang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(27), 9277-9287 (2012-07-06)
Ciliary neurotrophic factor (CNTF) is a potent neural cytokine with very low expression in the CNS, predominantly by astrocytes. CNTF increases rapidly and greatly following traumatic or ischemic injury. Understanding the underlying mechanisms would help to design pharmacological treatments to
Helena Parra-Acero et al.
Current biology : CB, 30(21), 4270-4275 (2020-08-29)
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in animals. They are heterodimeric transmembrane proteins that
Hiroyuki Yoshida et al.
Journal of gastroenterology, 58(8), 778-789 (2023-06-13)
Patients with primary sclerosing cholangitis (PSC) possess autoantibodies against biliary epithelial cells. However, the target molecules remain unknown. The sera of patients with PSC and controls were subjected to enzyme-linked immunosorbent assays to detect autoantibodies using recombinant integrin proteins. Integrin
Takeshi Kuwada et al.
Gastroenterology, 160(7), 2383-2394 (2021-02-15)
Ulcerative colitis is the most frequent type of inflammatory bowel disease and is characterized by colonic epithelial cell damage. Although involvement of autoimmunity has been suggested in ulcerative colitis, specific autoantigens/antibodies have yet to be elucidated. Using 23 recombinant integrin
Changsuk Moon et al.
Respiratory research, 10, 18-18 (2009-03-11)
Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t.) lipopolysaccharide (LPS) treatment and on the integrin signaled mitogen-activated protein
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