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一般描述
酰基辅酶 A 合成酶属于腺苷酸合成酶超家族。具有保守的三磷酸腺苷/单磷酸腺苷 (ATP/AMP) 结合基序。
应用
来自假单胞菌属的酰基辅酶 A 合成酶，已：
- 用作连接酶合成三磷酸腺苷 (ATP) 的甲羟戊酸衍生物
- 在 体外 脂肪酰化试验
- 合成 ( 14 C) 维诺辅酶 a (Va-CoA)，(3) ATP 的二磷酸盐衍生物 (4) 和 ( 3 H) 棕榈酸酯-CoA
酰基辅酶 A 合成酶可用于研究脂肪酸代谢和脂质代谢。已用于研究其与脂肪酸转运蛋白的相互作用，发现其参与脂肪细胞对长链脂肪酸的高效摄取 。
生化/生理作用
酰基辅酶 A (CoA) 合成酶 (ACS) 酶催化两步硫酯化反应，涉及游离脂肪酸 (FAs) 转化为 CoA 酯。ACS 的底物从 2 个碳至 26 个碳不等。参与脂类代谢 FAs 的激活，并使 FA 能够参与各种细胞代谢途径。
酰基辅酶 A 合成酶蛋白参与调节和促进哺乳动物细胞中长链脂肪酸的转运 。
单位定义
1 个单位将从 ATP 生成 1.0 μmol AMP 和油酰基辅酶 A，并在存在辅酶 A 的情况下在 pH 8.1 和 25 ℃ 下形成油酸盐。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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