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COO原产地证书/COA分析证书

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A002

N⁶-Cyclohexyladenosine

Name: N<SUP>6</SUP>-Cyclohexyladenosine
Brand: SIGMA

别名:

CHA

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About This Item

经验公式（希尔记法）:

C₁₆H₂₃N₅O₄

CAS号:

36396-99-3

分子量:

349.38

MDL编号:

MFCD00036808

UNSPSC代码:

12352204

PubChem化学物质编号:

329770564

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237825

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8.21202

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289922

磷酸三(2-乙基己基)酯

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8.21943

2-Ethylhexyl phosphate

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223301

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CDS003218

2-ethylhexyl phosphate

Sigma-Aldrich

SAB4503057

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A-002

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HPA015768

抗-S100B 兔抗

Sigma-Aldrich

130591

磷酸三(2-丁氧基乙基)酯

SMILES字符串

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCCC4)ncnc23

InChI

1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1

InChI key

SZBULDQSDUXAPJ-XNIJJKJLSA-N

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一般描述

N^6-Cyclohexyladenosine belongs to the class of new generation thermolytic agents.

生化/生理作用

N⁶-Cyclohexyladenosine is an adenosine A1 receptor agonist. It prevents thermogenesis and other response such as shivering in response to cold. N⁶-Cyclohexyladenosine initiates hibernation in animals.

替代产品

产品编号

说明

价格

C9901

N⁶-Cyclohexyladenosine

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine

Crosson CE, et al.

Investigative Ophthalmology & Visual Science, 46(10), 3795-3799 (2005)

Precise Control of Target Temperature Using N6-Cyclohexyladenosine and Real-Time Control of Surface Temperature

Laughlin BW, et al.

Therapeutic hypothermia and temperature management, 8(2), 108-116 (2018)

Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.

Gerard J Marek

Neuropharmacology, 56(8), 1082-1087 (2009-03-28)

Modulation of glutamatergic neurotransmission by metabotropic glutamate2/3 (mGlu2/3) receptor agonists effectively treats seemingly diverse neuropsychiatric illness such as generalized anxiety disorder and schizophrenia. Activation of adenosine A(1) heteroceptors, like mGlu2 autoreceptors, decreases glutamate release in the medial prefrontal cortex (mPFC)

Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons.

Matthew Edward Pamenter et al.

Brain research, 1213, 27-34 (2008-05-06)

Adenosine is a defensive metabolite that is critical to anoxic neuronal survival in the freshwater turtle. Channel arrest of the N-methyl-d-aspartate receptor (NMDAR) is a hallmark of the turtle's remarkable anoxia tolerance and adenosine A1 receptor (A1R)-mediated depression of normoxic

Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.

Domenico Tupone et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(36), 14512-14525 (2013-09-06)

Since central activation of A1 adenosine receptors (A1ARs) plays an important role in the induction of the hypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for the A1AR agonist N6-cyclohexyladenosine to induce a hypothermic, torpor-like state

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