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Merck
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55865

Sigma-Aldrich

地高辛NHS酯

≥80% (HPLC)

别名:

ε-（地高辛-3-0-乙酰氨基）己酸N-羟基琥珀酰亚胺酯, 地高辛NHS

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About This Item

经验公式（希尔记法）:
C35H50N2O10
CAS号:
129273-26-3
分子量:
658.78
MDL编号:
MFCD02093394
UNSPSC代码:
12352108
PubChem化学物质编号:
57651557
NACRES:
NA.25

方案

≥80% (HPLC)

表单

solid

运输

wet ice

储存温度

−20°C

SMILES字符串

[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@@H](C2)OCC(=O)NCCCCCC(=O)ON6C(=O)CCC6=O

InChI

1S/C35H50N2O10/c1-33-13-11-23(45-20-28(39)36-15-5-3-4-6-31(42)47-37-29(40)9-10-30(37)41)17-22(33)7-8-25-26(33)18-27(38)34(2)24(12-14-35(25,34)44)21-16-32(43)46-19-21/h16,22-27,38,44H,3-15,17-20H2,1-2H3,(H,36,39)/t22-,23+,24-,25-,26+,27-,33+,34+,35+/m1/s1

InChI key

KHNDABJZSPPYLE-FUGFVFQCSA-N

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应用

地高辛配基NHS酯可用于制备链霉亲和素-地高辛配基偶联物和地高辛重组Ara h1（花生成分）偶联物，用于酶联免疫吸附试验(ELISA)。

生化/生理作用

地高辛配基(Digoxigenin)是一种糖苷配基，是具有药理活性的植物毒素。效力低于地高辛。低剂量可治疗心脏疾病。地高辛配基常与另一种载荷偶联，使其活性降低或更不易进入组织。由于地高辛配基永久性连接载荷并被其完全覆盖，因而无法用作活性基团。
地高辛配基NHS酯是一种活化酯，在温和条件下与氨基反应，将地高辛配基连接蛋白质或5′-氨基取代的寡核苷酸地高辛配基标记用于免疫标记分子，以使用具有高亲和力和特异性的抗地高辛配基抗体进行检测。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM3603
BCCM0721
BCCM0773
BCCJ7940
BCCH9725

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R Antolovic et al.
The Journal of biological chemistry, 273(26), 16259-16264 (1998-06-20)
Searching for a binding protein in blood, which may be involved in the specific transport of cardiac glycosides to their receptor sites on the sodium pump, we isolated a cardiac glycoside-binding protein (CGBG) of 26 kDa from the globulin fraction
R Antolovic et al.
FEBS letters, 368(1), 169-172 (1995-07-10)
The digoxigenin derivative N-hydroxysuccinimidyl digoxigenin-3-O-methylcarbonyl-epsilon-aminocaproate (HDMA) has been shown to covalently label the ouabain binding site of the Na,K-ATPase epsilon subunit [Antolovic et al. (1995) Eur. J. Biochem. 227, 61-67]. In the present study we observed both, labeling and inactivation
J Olejnik et al.
Nucleic acids research, 26(15), 3572-3576 (1998-07-22)
We report the design and evaluation of two non-nucleosidic photocleavable aminotag phosphor-amidites. These reagents introduce a photocleavable amino group on the 5'-terminal phosphate of synthetic oligonucleotides. The 5' photocleavable amino group enables introduction of a variety of amine-reactive markers onto
Silke Metz et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(20), 8194-8199 (2011-05-04)
Bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) were generated for targeted payload delivery. Targeting moieties are IgGs that bind the tumor antigens Her2, IGF1R, CD22, or LeY. A Dig-binding single-chain Fv was attached in disulfide-stabilized form
Hazal B Kose et al.
Nature communications, 11(1), 3713-3713 (2020-07-28)
A ring-shaped helicase unwinds DNA during chromosome replication in all organisms. Replicative helicases generally unwind duplex DNA an order of magnitude slower compared to their in vivo replication fork rates. However, the origin of slow DNA unwinding rates by replicative
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