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Merck
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文件

50644

Sigma-Aldrich

N-羟乙酰神经氨酸

≥95% (HPLC)

别名:

Neu5Glc, NeuNGl

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About This Item

经验公式（希尔记法）:
C11H19NO10
CAS号:
1113-83-3
分子量:
325.27
Beilstein:
1716828
MDL號碼:
MFCD00057551
分類程式碼代碼:
12352201
PubChem物質ID:
57651263

生物源

synthetic

化驗

≥95% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

[H][C@]1(O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O)[C@H](O)[C@H](O)CO

InChI

1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/t4-,5+,7+,8+,9+,11-/m0/s1

InChI 密鑰

FDJKUWYYUZCUJX-AJKRCSPLSA-N

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應用

甘氨酰神经氨酸，一种非人类乳汁和初乳的成分，被用作引用来分析泌乳期中甘氨酸的变化。甘氨酰神经氨酸是一种异种抗原，在异种移植过程中参与抗原反应（抗体介导的超急性排斥反应）。

其他說明

为了全面了解我们针对客户研究提供的各种单糖产品，建议您访问我们的碳水化合物分类页面。
N-羟乙酰神经氨酸在大鼠和小鼠肝脏中生物合成的调节
销售限制可能适用

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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A Lepers et al.
European journal of biochemistry, 193(3), 715-723 (1990-11-13)
The relative contribution of N-glycoloyl-beta-D-neuraminic acid (Neu5Gc) to total sialic acids expressed in mouse and rat liver glycoconjugates was found to be 95% and 11%, respectively. This considerable difference in sialic acid composition made these two tissues suitable models for
Rachel E Taylor et al.
The Journal of experimental medicine, 207(8), 1637-1646 (2010-07-14)
The nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is metabolically incorporated into human tissues from certain mammalian-derived foods, and this occurs in the face of an anti-Neu5Gc "xeno-autoantibody" response. Given evidence that this process contributes to chronic inflammation in some diseases
Véronique Spichtig et al.
Analytical biochemistry, 405(1), 28-40 (2010-06-18)
Sialic acids are becoming recognized as important components of milk-based products for infants and young children. As such, many companies now label the sialic acid content of their products. To control the labeling, suitable methods are required for this analysis.
Qiaozhen Lu et al.
Analytical chemistry, 84(6), 2761-2768 (2012-03-07)
Human polyclonal IgG antibodies directly against the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) are potential biomarkers and mechanistic contributors to cancer and other diseases associated with chronic inflammation. Using a sialoglycan microarray, we screened the binding pattern of such antibodies
Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk.
Vered Padler-Karavani et al.
Xenotransplantation, 18(1), 1-5 (2011-02-24)
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