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About This Item
经验公式（希尔记法）:
C20H27N · C6H8O7
CAS号:
分子量:
473.56
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
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等级
pharmaceutical primary standard
API类
alverine
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2
InChI
1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI key
RYHCACJBKCOBTJ-UHFFFAOYSA-N
基因信息
human ... HNF4A(3172) , HTR1A(3350)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Used for studies of pharmacological activity including:
- Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
- Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
- Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
- Drug effects viewed from a signal transduction network perspective
- Enhanced cytotoxic effect of proteasome inhibitor MG132
- Mechanism of action on phasic smooth muscles
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M Bouvier et al.
Gastroenterologie clinique et biologique, 16(4), 334-338 (1992-01-01)
To analyse the mechanisms of the antispasmodic action of alverine, the effects of this drug on the spontaneous motility and nervous control of the proximal colon of the rabbit were studied in vivo. The electrical activity of the colonic smooth
A general practice study to compare alverine citrate with mebeverine hydrochloride in the treatment of irritable bowel syndrome.
G J Tudor
The British journal of clinical practice, 40(7), 276-278 (1986-07-01)
D Malka et al.
Journal of hepatology, 27(2), 399-403 (1997-08-01)
We report the case of a 67-year-old woman in whom onset and regression of acute hepatitis were closely related to the time of administration and withdrawal of the smooth muscle relaxant alverine. Antinuclear antibodies were positive, and their titer followed
[Recurrent liver involvement induced by alverine].
M Zenut et al.
Therapie, 52(1), 78-79 (1997-01-01)
Yavuz Beyazit et al.
Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 34(5), 352-355 (2011-10-08)
The quality of colon cleansing and the tolerance of patients to the procedure are two major determinants of the quality of a colonoscopy. Many bowel-cleansing regimens are known, but there is no ideal regimen. Alverine citrate (Relaxyl, Spasmonal) is a
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