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Merck

PHR1768

Supelco

地塞米松磷酸钠

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

地塞米松-21-磷酸二钠盐 二钠盐

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About This Item

经验公式(希尔记法):
C22H28FNa2O8P
CAS号:
分子量:
516.40
Beilstein:
6473066
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP 108
traceable to Ph. Eur. D0720000
traceable to USP 1177032

API 家族

dexamethasone

CofA

current certificate can be downloaded

包裝

pkg of 1 g

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChI 密鑰

PLCQGRYPOISRTQ-FCJDYXGNSA-L

基因資訊

human ... NR3C1(2908)

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一般說明

Dexamethasone is a glucocorticoid and an anti-inflammatory agent, widely used in ocular inflammatory diseases.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

Dexamethasone Sodium Phosphate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using differential pulse polarography technique and high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAC1690 in the slot below. This is an example certificate only and may not be the lot that you receive.

相關產品

产品编号
说明
价格

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Trace determination of dexamethasone sodium phosphate in pharmaceutical formulations by differential pulse polarography
Jeyaseelan C and Joshi PA
Analytical and Bioanalytical Chemistry, 373(8), 772-776 (2002)
Simultaneous determination of gatifloxacin and dexamethasone sodium phosphate in bulk and pharmaceutical formulations by HPLC
Sireesha RK, et al.
African Journal of Pharmacy and Pharmacology, 5(17), 1990-1995 (2011)
Tzu-Chieh Chen et al.
The Journal of biological chemistry, 294(23), 9213-9224 (2019-05-06)
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for hypertriglyceridemia and hepatic steatosis induced by the synthetic

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