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07386

Supelco

辅酶 Q10

analytical standard

别名:

Q-10, 辅酶Q10, 辅酶Q50

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About This Item

经验公式（希尔记法）:
C59H90O4
CAS号:
303-98-0
分子量:
863.34
Beilstein:
1900141
EC 号:
206-147-9
MDL编号:
MFCD00042919
UNSPSC代码:
85151701
PubChem化学物质编号:
329748422
NACRES:
NA.24

等级

analytical standard

质量水平

100

方案

≥97.5% (HPLC)

表单

powder

保质期

limited shelf life, expiry date on the label

杂质

≤1.0% water

颜色

faint yellow to dark orange

mp

49 °C

应用

cleaning products
cosmetics
food and beverages
personal care

包装形式

neat

储存温度

−20°C

SMILES字符串

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

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相关类别

一般描述

辅酶Q10是线粒体呼吸链中的中心电子载体，来源于食物摄入以及内源合成。它通常以还原形式起作用，可防止生物膜和血清低密度脂蛋白（LDL）中的脂质过氧化。它往往可以保护线粒体膜蛋白和DNA免受脂质过氧化引起的氧化损伤。

应用


  • Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice：研究表明辅酶Q10可通过抗氧化机制和炎症调节有效减轻心脏损伤，提供人体治疗参考(Antar et al., 2024)。

  • Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10：研究辅酶Q10及牛磺酸如何缓解氯丙嗪所致血液不良反应，体现它对付精神治疗副反应的作用(Obukohwo et al., 2024)。

  • Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms：讨论辅酶Q10在肌肉健康中的作用，尤其它可通过线粒体支持防止肌肉萎缩并增强细胞能量代谢，与运动医学和衰老研究紧密相关(Shen et al., 2024)。

  • Identification of a family of species-selective complex I inhibitors as potential anthelmintics：本文与辅酶Q10间接相关，研究重点涉及的线粒体功能，与辅酶Q10在同类通路上的作用有关。代表在寄生虫学和传染病领域的新应用意义(Davie et al., 2024)。

注意

光敏感

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储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM8079
BCCL4259
BCCL4255
BCCJ0835
BCCF6674

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Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults
Niklowitz P, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 342(1-2), 219-226 (2004)
Marnie Potgieter et al.
Nutrition reviews, 71(3), 180-188 (2013-03-05)
Coenzyme Q10 (CoQ10) is the only lipid-soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known for its role in the electron transport chain in mitochondrial membranes during aerobic cellular respiration.
Adarsh Kumar et al.
Pharmacology & therapeutics, 124(3), 259-268 (2009-07-30)
Coenzyme Q10 (ubiquinone) is a mitochondrial coenzyme which is essential for the production of ATP. Being at the core of cellular energy processes it assumes importance in cells with high energy requirements like the cardiac cells which are extremely sensitive
Gian Paolo Littarru et al.
Nutrition (Burbank, Los Angeles County, Calif.), 26(3), 250-254 (2009-11-26)
The fundamental role of coenzyme Q(10) (CoQ(10)) in mitochondrial bioenergetics and its well-acknowledged antioxidant properties constitute the basis for its clinical applications, although some of its effects may be related to a gene induction mechanism. Cardiovascular disease is still the
Igor Pravst et al.
Critical reviews in food science and nutrition, 50(4), 269-280 (2010-03-20)
Coenzyme Q10 (CoQ(10)) is an effective natural antioxidant with a fundamental role in cellular bioenergetics and numerous known health benefits. Reports of its natural occurrence in various food items are comprehensively reviewed and critically evaluated. Meat, fish, nuts, and some
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