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生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
1D11.1, monoclonal
物種活性
human
技術
western blot: suitable
同型
IgG2aκ
NCBI登錄號
UniProt登錄號
目標翻譯後修改
unmodified
基因資訊
human ... OAS1(4938)
一般說明
2′-5′-oligoadenylate synthase 1 (EC 2.7.7.84; UniProt P00973; also known as (2-5′)oligo(A) synthase 1, 2-5A synthase 1, E18/E16, p46/p42 OAS) is encoded by the OAS1 (also known as OIAS, OIASI) gene (Gene ID 4938) in human. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), including pathogens-derived double-stranded RNA and DNA (dsRNA and dsDNA). The 2′-5′ oligoadenylate synthetases (OAS) are interferon-induced cytoplasmic PRRs that recognize virally produced dsRNA and initiate RNA destabilization through activation of RNase L within infected cells. Upon dsRNA binding, OAS enzymes generate the second messenger 2’-5’ oligoadenylate (2-5An; n = 2 to 19), resulting in the dimerization and activation of the latent ribonuclease (RNase L) that degrades host and viral mRNAs. In primates, the OAS family consists of OAS1, OAS2, OAS3, and the catalytically inactive OASL, while 12 rodent Oas genes have been identified, eight of which are OAS1 paralogs.
特異性
Clone 1D11.1 was raised against a recombinant fragment derived from the spliced isoform p46 (E18; Uniprot P00973-1), cross-reactivity toward the p41 (E16; 3-9), p48 (9-2), and p44 spliced isoforms is possible, but has not been determined.
免疫原
Epitope: Internal (C-terminal half).
GST-tagged recombinant internal fragment from the C-terminal half of human OAS1.
應用
Anti-OAS1 Antibody, clone 1D11.1 is an antibody against OAS1 for use in Western Blotting.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
RNA Metabolism & Binding Proteins
RNA Metabolism & Binding Proteins
品質
Evaluated by Western Blotting in lysate of IFN gamma-treated HeLa cells.
Western Blotting Analysis: A 1:500 dilution of this antibody detected OAS1 in 10 µg of lysate from IFN gamma-treated HeLa cells.
Western Blotting Analysis: A 1:500 dilution of this antibody detected OAS1 in 10 µg of lysate from IFN gamma-treated HeLa cells.
標靶描述
~50 kDa observed. 46.03 kDa (isoform p46; E18), 41.74 kDa (isoform p41; E16; 3-9), 47.41 kDa (isoform p48; 9-2), and 43.94 kDa (isoform p44) calculated.
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Runhong Zhou et al.
Journal of virology, 92(6) (2017-12-22)
Although it has been shown that some mannose-binding lectins (MBLs) exhibit significant activity against HIV infection, little is known about whether N-acetylgalactosamine (GalNAc)-binding lectins have the ability to inhibit HIV infection. Here, we demonstrate that a soybean-derived lectin (SBL) with
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