ABC937

Anti-FOXL1 Antibody

from rabbit, purified by affinity chromatography

• 别名: Forkhead box protein L1, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7, FREAC-7, FOXL1
• UNSPSC代码: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 纯化方式: affinity chromatography
• 种属反应性: human
• 种属反应性（根据同源性预测）: sheep (based on 100% sequence homology), feline (based on 100% sequence homology), porcine (based on 100% sequence homology), bovine (based on 100% sequence homology), horse (based on 100% sequence homology)
• 技术: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI登记号: NP_005241
• UniProt登记号: Q12952
• 运输: wet ice
• 靶向翻译后修饰: unmodified
• 基因信息: human ... FOXL1(2300)

说明

一般描述

Forkhead box protein L1 (UniProt Q12952; also known as Forkhead-like 11, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7, FREAC-7) is encoded by the FOXL1 (also known as FKHL11, FREAC7) gene (Gene ID 2300) in human. FOXL1 protein belongs to the forehead box (Fox) family of transcription factors characterized by a common DNA-binding domain (the forkhead box). FOXL1 is involved in regulating the proliferation of gastrointestinal epithelial cells. Loss of Foxl1 leads to distorted architecture of the stomach and small intestine in mice due to a markedly increased epithelial proliferation. Foxl1 knockout is correlated with an enhanced Wnt/β-catenin pathway activation as evidenced by increased β-catenin nuclear localization. FOXL1 expression is down-regulated in the majority of human clear cell renal cell carcinoma (ccRCC), at both mRNA and protein levels. FOXL1 expression inversely correlates with the aggressive phenotype of ccRCC and the survival outcome of patients.

免疫原

KLH-conjugated linear peptide corresponding to human FOXL1.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FOXL1 in human breast cancer tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-FOXL1 Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of FOXL1.

质量

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected FOXL1 in 10 µg of human colon tissue lysate.

目标描述

~36 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable