8.51029

N-Biotinyl-NH-(PEG)₂-COOH . DIPEA (20 atoms)

Novabiochem^®

• 别名: N-Biotinyl-NH-(PEG)₂-COOH . DIPEA (20 atoms), O-(N-Biotinyl-3-aminopropyl)-O′-(N-glutaryl-3-aminopropyl)-diethyleneglycol · DIPEA
• 经验公式（希尔记法）: C₂₅H₄₄N₄O₈S · xC₈H₁₉N
• CAS号: 1205744-09-7
• 分子量: 560.70
• MDL號碼: MFCD08458689
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• 品質等級: 200
• 產品線: Novabiochem^®
• 化驗: ≥95.0% (HPLC); ≥98% (TLC)
• 形狀: powder
• 反應適用性: reaction type: Biotinylations
• 製造商／商標名: Novabiochem^®
• mp: 131-136 °C
• 應用: peptide synthesis
• 儲存溫度: 2-8°C
• SMILES 字串: S1[C@H]([C@H]2NC(=O)N[C@H]2C1)CCCCC(=O)NCCOCCOCCOC(=O)O.N(C(C)C)(C(C)C)CC
• InChI: 1S/C17H29N3O7S.C8H19N/c21-14(18-5-6-25-7-8-26-9-10-27-17(23)24)4-2-1-3-13-15-12(11-28-13)19-16(22)20-15;1-6-9(7(2)3)8(4)5/h12-13,15H,1-11H2,(H,18,21)(H,23,24)(H2,19,20,22);7-8H,6H2,1-5H3/t12-,13-,15-;/m0./s1
• InChI 密鑰: YOALVTBRBBZXGM-HZPCBCDKSA-N

说明

一般說明

The use of this novel biotin derivative incorporates a hydrophilic 20 atom PEG spacer between the peptide and biotin. This not only greatly improves the solubility of the resultant peptide, but reduces steric hindrance between the peptide and biotin, leading to better avidin binding and higher biological activity. The biotin-PEG derivative can be easily incorporated using any standard coupling method as the final step in SPPS, immediately prior to cleavage of the peptide from the resin.

Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis

聯結

Replaces: 01-63-0133

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (50 mg in 1 ml NMP): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable