681500

WHI-P180

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.

• 别名: WHI-P180, 4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
• 经验公式（希尔记法）: C₁₆H₁₅N₃O₃
• CAS号: 211555-08-7
• 分子量: 297.31
• MDL编号: MFCD02683970
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: pale yellow
• 溶解性: DMSO: 50 mg/mL
• 运输: ambient
• 储存温度: 2-8°C
• SMILES字符串: N(c3cc(ccc3)O)c1ncnc2c1cc(c(c2)OC)OC
• InChI: 1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
• InChI key: BNDYIYYKEIXHNK-UHFFFAOYSA-N

说明

一般描述

A potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC₅₀ = 1 µM) by blocking the ATP site.

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC₅₀ = 1 µM) by blocking the ATP site.

生化/生理作用

Cell permeable: no

Primary Target
Cdk2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1 µM for Cdk2

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable