476480

PKC 20-28, Cell-Permeable, Myristoylated

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ).

• 别名: PKC 20-28, Cell-Permeable, Myristoylated, Myr-N-FARKGALRQ-NH₂, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Protein Kinase C 20-28, Cell-Permeable, Myristoylated, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH₂, Protein Kinase C 20-28, Cell-Permeable, Myristoylated
• 经验公式（希尔记法）: C₆₀H₁₀₆N₁₈O₁₁
• 分子量: 1255.60
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 溶解度: water: 10 mg/mL; Tris-HCl, pH 7.5: 25 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

Pseudosubstrate sequence from protein kinase C_α and β ( PKC_α and PKC_β). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC₅₀ = 8 µM); exhibits 98% inhibition at 100 µM.

Pseudosubstrate sequence from protein kinase Ca (PKC_α) and PKC_β. N-terminal myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC₅₀ = 8 µM). Exhibits 98% inhibition at 100 µM.

生化／生理作用

Cell permeable: yes

Primary Target
TPA activation of MARCKS phosphorylation in fibroblast primary cultures

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures

包裝

Yes

警告

Toxicity: Standard Handling (A)

序列

N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

其他說明

Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable