203895

BTS

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility.

• 别名: BTS, N-Benzyl- p-toluenesulphonamide, N-Benzyl-p-toluenesulphonamide
• 经验公式（希尔记法）: C₁₄H₁₅NO₂S
• CAS号: 1576-37-0
• 分子量: 261.34
• MDL编号: MFCD00159328
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 描述: RTECS - XT5490000
• 方案: ≥95% (HPLC)
• 表单: crystalline solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white
• 溶解性: DMSO: 200 mg/mL
• 运输: ambient
• 储存温度: 2-8°C
• SMILES字符串: [S](=O)(=O)(NCc2ccccc2)c1ccc(cc1)C
• InChI: 1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3
• InChI key: WTHKAJZQYNKTCJ-UHFFFAOYSA-N

说明

一般描述

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

An aryl sulphonamide that acts as a potent inhibitor of Ca²⁺-stimulated myosin S1 actin-stimulated ATPase activity (IC₅₀ = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC₅₀ = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC₅₀<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.

生化/生理作用

Cell permeable: no

Primary Target
Ca²⁺-stimulated myosin S1 ATPase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: ~5 µM against Ca2+-stimulated myosin S1 ATPase

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Cheung, A., et al. 2002. Nat. Cell Biol.4, 83.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable