126850

α₁-PDX, Human, Recombinant, E. coli

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag.

• 别名: α₁-Antitrypsin Portland
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥80% (SDS-PAGE)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: do not freeze
• 溶解度: water: 2.5 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C

说明

一般說明

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His·Tag and a FLAG·Tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (K_i = 600 pM). α1-PDX can be used in extracellular applications to block the processing of furin substrates. α1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.

Recombinant protein derived from the bioengineered human α₁-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (K_i = 600 pM). Extracellular application of α₁-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.

生化／生理作用

Cell permeable: no

Primary Target
Furin-dependent processing of protein precursors

Product does not compete with ATP.

Reversible: no

Target K_i: 600 pM against furin-dependent processing of protein precursors

包裝

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

外觀

Lyophilized from PBS.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 7293.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable