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生物源
rabbit
品質等級
抗體表格
culture supernatant
抗體產品種類
primary antibodies
無性繁殖
A5S, monoclonal
物種活性
human, zebrafish, mouse, canine
製造商／商標名
Upstate®
技術
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
phosphorylation (pSer465/pSer467)
基因資訊
human ... SMAD2(4087)
一般說明
SMAD2或MAD-mothers against decapentaplegic-homolog是一种多肽，顾名思义，是果蝇基因：“Mothers against decepentaplegic”的同系物它属于SMAD蛋白家族，该家族又属于TGFb调节子超家族。像其他许多TGFb家族成员一样，SMAD2液参与细胞信号转导的调节。SMAD2可调节激活素和TGFb′s的信号。它可与SMAD锚相互作用激活受体（SARA）。配体的结合会引起SMAD2蛋白的磷酸化，从而与SARA的解离并与SMAD4缔合。随后，它被转移至细胞核，与其他蛋白质形成复合物并充当转录因子。SMAD2是受受体调节的SMAD（R-SMAD），并由骨形态发生蛋白1型受体激酶激活。
特異性
根据序列同源性预测与非洲爪蟾发生交叉反应。
识别磷酸化Smad2。与Smad3没有交叉反应。
免疫原
对应于人Smad2 Ser465/467位点周围氨基酸[pS]M[pS]的KLH偶联合成肽
應用
使用抗磷酸化Smad2（Ser465/467）抗体，克隆A5S（兔单克隆抗体）检测磷酸化Smad2（Ser465/467），该抗体已证明可在WB中发挥作用。
品質
已通过免疫印迹分析进行常规评估。
標靶描述
55-60 kDa
聯結
替代：05-953
分析報告
对照
HL60细胞裂解液，经TGFa处理的HepG2细胞或经TGF处理的HepG2细胞β
HL60细胞裂解液，经TGFa处理的HepG2细胞或经TGF处理的HepG2细胞β
其他說明
浓度：请参考批次特异性浓缩物的分析证书。
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
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