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等級
certified reference material
品質等級
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
drug control
Narcotic Licence Schedule A (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)
濃度
1.0 mg/mL in methanol (as salt)
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
forensics and toxicology
形式
single component solution
儲存溫度
−20°C
SMILES 字串
OCCCC([O-])=O.[Na+]
InChI
1S/C4H8O3/c5-3-1-2-4(6)7/h5H,1-3H2,(H,6,7)/p-1
InChI 密鑰
SJZRECIVHVDYJC-UHFFFAOYSA-M
一般說明
GHB，或γ-羟基丁酸酯，是一种以Xyrem®品牌名出售的中枢神经系统抑制剂，并可医用于治疗发作性睡病、白天过度嗜睡以及极少数情况下的酗酒。GHB还被娱乐性地用作麻醉剂和约会强奸药。它众多的俗称包括“GBH”、“X液体”、“G”、“果汁”和“密耳”。
應用
- 睡眠障碍研究中的GHB钠盐：一项关于夜用羟丁酸钠（GHB钠盐的一种形式）的研究表明，觉醒时前扣带皮层的磁共振谷氨酸信号增强，这说明羟丁酸钠在睡眠研究中有调节大脑功能的潜在应用（Dornbierer et al., 2023）。
- GHB-Na+在酒精成瘾治疗中的研究：研究侧重于γ-羟基丁酸钠盐（GHB）治疗酒精成瘾的功效，它能让人有效地维持禁欲，减少对酒精的渴望，降低复发率（Frisoni et al., 2023）。
- 用于体外生化测定的γ-羟基丁酸钠：研究人员对受酒精干扰的大鼠体内γ-羟基丁酸酯（GHB）的药代动力学和代谢进行了详细研究，该研究为GHB生化行为和与酒精的相互作用的体外研究提供了一个模板（Kim et al., 2023）。
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Xyrem is a registered trademark of JPI Commercial, LLC
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
其他客户在看
Jae Seong Lee et al.
Journal of biotechnology, 161(1), 34-41 (2012-06-26)
Previous research showed that co-down-regulation of caspase-3/7 in rCHO cells, unlike Bcl-2 overexpression, did not effectively block apoptotic cell death induced by 3mM sodium butyrate (NaBu). Here, it is found that the control of autophagy is also related to this
John M Roll et al.
Journal of the experimental analysis of behavior, 97(3), 323-331 (2012-06-14)
Gamma-hydroxybutyrate (GHB) is a drug with significant abuse potential. The present study aimed to assess the relative value of escalating doses of GHB to current GHB users via the Multiple Choice Procedure (MCP), and to validate that the dose rated
Free speech rights outweigh restrictions on promoting drugs off label, court rules.
Bob Roehr
BMJ (Clinical research ed.), 345, e8324-e8324 (2012-12-12)
Elisabetta Bertol et al.
Journal of pharmaceutical and biomedical analysis, 70, 518-522 (2012-08-14)
A gas chromatography-mass spectrometry (GC-MS) and a liquid chromatography tandem mass spectrometry (LC-MS/MS) method were validated for quantifying endogenous and exogenous hair concentrations of gamma-hydroxybutyrate (GHB). The GC-MS method is based on overnight extraction of 25 mg hair in NaOH
γ-Hydroxybutyrate toxicity mimicking basilar artery stroke.
N S N Graham et al.
British journal of hospital medicine (London, England : 2005), 73(7), 412-413 (2012-08-10)
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