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化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 100 μg (with stopper and crimp cap (850174P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850174P-500ug))
製造商/商標名
Avanti Research™ - A Croda Brand 850174P
脂質類型
phospholipids
cardiolipins
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCC)=O)COC(CCCCC)=O.[NH4+].[NH4+].[NH4+]
一般說明
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is an inositol phospholipid, which accounts for approximately 0.05-0.1% of total cellular phosphatidylinositol (PI). In fungi and higher eukaryotes, this less abundant phosphoinositide is present in the endosomal and lysosomal membranes.
生化/生理作用
Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is capable of activating ion channels on endosomes and lysosomes. It also activates mammalian target of rapamycin complex 1 (mTORC1) in yeast and in some mammalian cell types.
包裝
2 mL Amber Serum Vial with Stopper and Crimp Cap (850174P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850174P-500ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Molecular biology of the cell, 25(8), 1251-1262 (2014-02-14)
Vacuolar proton-translocating ATPases (V-ATPases) are highly conserved, ATP-driven proton pumps regulated by reversible dissociation of its cytosolic, peripheral V1 domain from the integral membrane V(o) domain. Multiple stresses induce changes in V1-V(o) assembly, but the signaling mechanisms behind these changes
Cell structure and function, 42(1), 49-60 (2017-03-18)
In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial
Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical
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