902543

Propargyl-PEG4-acid

• 别名: 4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH₂CO₂H
• 经验公式（希尔记法）: C₁₂H₂₀O₆
• CAS号: 1415800-32-6
• 分子量: 260.28
• MDL號碼: MFCD22683284
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• 形狀: liquid
• 反應適用性: reagent type: linker
• 存貨情形: available only in USA
• 折射率: n/D 1.460
• 密度: 1.164 g/mL
• 官能基: alkyne; carboxylic acid
• 儲存溫度: −20°C
• SMILES 字串: OC(CCOCCOCCOCCOCC#C)=O

说明

應用

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

其他說明

Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 象形圖: GHS02
• 訊號詞: Danger
• 危險聲明: H242
• 防範說明: P210 - P234 - P235 - P240 - P370 + P378 - P403
• 危險分類: Self-react. C
• 儲存類別代碼: 5.2 - Organic peroxides and self-reacting hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable