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379409

Sigma-Aldrich

1,2-二甲基-3-羟基-4-吡啶酮

98%

别名:

去铁酮

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About This Item

经验公式（希尔记法）:
C7H9NO2
CAS号:
30652-11-0
分子量:
139.15
MDL编号:
MFCD00134497
UNSPSC代码:
12352100
PubChem化学物质编号:
24863630
NACRES:
NA.22

质量水平

100

方案

98%

表单

powder

mp

272-275 °C (lit.)

官能团

ketone

SMILES字符串

CN1C=CC(=O)C(O)=C1C

InChI

1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

InChI key

TZXKOCQBRNJULO-UHFFFAOYSA-N

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相关类别

一般描述

3-羟基-1,2-二甲基-4(1H)-吡啶酮（Hdpp，去铁酮）是一种羟基酮衍生物。 它在酸性水溶液中与铀酰盐[UO2(NO3)2]反应，得到单核复合物（[UO2(dpp)(Hdpp)2(H2O)]ClO4）。 已通过X射线研究分析了这些复合物的结构和几何结构。

应用

3-羟基-1,2-二甲基-4(1H)-吡啶酮（OH-吡啶酮）可用于杀菌试验。它已被用作羟基酮螯合剂，并且已经评估了其对人口腔正常和肿瘤细胞的细胞毒作用。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

预防措施声明

P301 + P312 + P330

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
STBL1267
STBL1268
STBK5488
STBJ7316
STBJ3298

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Chryssoula Drouza et al.
Inorganic chemistry, 43(26), 8336-8345 (2004-12-21)
Reaction of [UO(2)(NO(3))(2)] with the hydroxy ketones 3-hydroxy-2-methyl-4-pyrone (Hma) and 3-hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp) in aqueous acidic solutions (pH approximately 3) yields the compounds [UO(2)(ma)(2)(H(2)O)].H(2)O (1.H(2)O) and [UO(2)(dpp)(Hdpp)(2)(H(2)O)]ClO(4) (2), respectively. X-ray diffraction shows that the geometry around the metal ion in both
Eiji Yasumoto et al.
Anticancer research, 24(2B), 755-762 (2004-05-27)
Hydroxyketone chelators, deferiprone (HK1), maltol (HK3) and their related compounds (HK2, 4-8), were characterized for their cytotoxic profiles against oral human normal and tumor cells. Most hydroxyketones except HK6 showed relatively higher tumor-specific cytotoxicity. Deferiprone (HK1), which showed the highest
Etheresia Pretorius et al.
Toxicology mechanisms and methods, 23(5), 352-359 (2013-01-03)
Inflammatory diseases associated with iron overload are characterized by a changed coagulation profile, where there is a persistent presence of fibrin-like material of dense-matted deposits (DMDs). It is believed that one source of such material is a result of the
Jaroslav Cermak et al.
Leukemia research, 37(12), 1612-1615 (2013-08-14)
One hundred thirteen patients with myelodysplastic syndromes (MDS) with <10% of bone marrow blasts received either deferiprone in a daily dose of 40-90 mg/kg (48 patients) or deferasirox in a daily dose of 10-40 mg/kg (65 patients). Median duration of
Carole Peyssonnaux et al.
The Journal of clinical investigation, 115(7), 1806-1815 (2005-07-12)
Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) to myeloid cell innate immune function. HIF-1alpha
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