901573

Bromo-PEG₁-acid

≥95%

• Fórmula empírica (notación de Hill): C₅H₉BrO₃
• Número de CAS: 1393330-33-0
• Peso molecular: 197.03
• MDL number: MFCD22574802
• UNSPSC Code: 12352101

Propiedades

• assay: ≥95%
• form: powder, crystals or chunks
• reaction suitability: reagent type: linker
• functional group: bromo; carboxylic acid
• storage temp.: −20°C
• SMILES string: BrCCOCCC(O)=O

Descripción

Application

Bromo-PEG₁-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₁-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains a single PEG unit to help improve solubility.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3