901568

Bromo-PEG₃-acid

• Fórmula empírica (notación de Hill): C₉H₁₇BrO₅
• Número de CAS: 782475-35-8
• Peso molecular: 285.13
• Número MDL: MFCD22574820
• Código UNSPSC: 12352101
• NACRES: NA.22

Propiedades

• Formulario: liquid
• idoneidad de la reacción: reagent type: linker
• grupo funcional: bromo; carboxylic acid
• temp. de almacenamiento: −20°C
• cadena SMILES: BrCCOCCOCCOCCC(O)=O
• Clave InChI: OKWHCSUISPMYIJ-UHFFFAOYSA-N

Descripción

Aplicación

Bromo-PEG₃-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₃-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3