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Key Documents

M7504

Sigma-Aldrich

Mannan from Saccharomyces cerevisiae

prepared by alkaline extraction

Synonyme(s) :

D-Mannan

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About This Item

Numéro CAS:
9036-88-8
Numéro MDL:
MFCD00131574
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.25

Source biologique

bakers yeast (whole cell)

Niveau de qualité

300

Forme

powder

Activité optique

[α]/D 73 to 89 °, c = 1% (w/v) in water

Impuretés

<1.0% Low molecular weight saccharides (TLC)

Couleur

beige

Solubilité

water: ~50 g/L

Traces de cations

Na: <2%

Température de stockage

2-8°C

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Catégories apparentées

Description générale

Mannan is the main component of yeast cell wall polysaccharides broadly present in nature, such as in plants, bacteria, yeasts, and other organisms. It comprises a highly branched complex carbohydrate, an α-1,6 backbone with α-1,2- and α-1,3-attached mannose side chains.

Application

Mannan from Saccharomyces cerevisiae has been used to coat the microtiter wells to quantify the levels of mannose-binding lectin (MBL) using a mannan-binding enzyme-linked immunosorbent assay (ELISA).
Mannan from Saccharomyces cerevisiae has been used in a study to assess nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages. It has also been used in a study to investigate new lectins from bulbs of Croccus sativum.

Actions biochimiques/physiologiques

Mannan exhibits several biological properties, including antiproliferative, antioxidant, and immunomodulatory. It is used as a hardener ingredient and as an emulsion stabilizer. Mannan is also involved in the inhibition of pathogen adherence, regulation of bacterial growth, and enhancement of the immune response.

Notes préparatoires

Prepared by method of Haworth.

Autres remarques

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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J A Roecklein et al.
The Journal of laboratory and clinical medicine, 119(6), 772-781 (1992-06-11)
The uptake of Mycobacterium avium complex (MAC) microorganisms by human peripheral blood monocytes (PBMs) and alveolar macrophages (AMs) is not well understood. We have previously shown, under opsonic conditions, that humoral factors are important in mediating the uptake of MAC
Y Oda et al.
Biological & pharmaceutical bulletin, 16(10), 978-981 (1993-10-01)
Four isolectins were isolated from bulbs of Croccus sativum (saffron), using affinity chromatography on mannan-Sepharose 4B, gel filtration and ion-exchange column chromatography in the presence of 8 M urea. The relative molecular masses of these lectins were determined by gel
Michael L Patnode et al.
Cell, 179(1), 59-73 (2019-09-21)
Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with
Polysaccharides. Part XXIV. Yeast mannan.
Haworth, W.N., et al.
Journal of the Chemical Society, 784-791 (1937)
Severin Vogt et al.
Frontiers in immunology, 11, 562564-562564 (2020-10-27)
The role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via activation of the
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