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M5284

Sigma-Aldrich

IgG1 Isotype Control from murine myeloma

clone MOPC 21, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Isotype control antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Niveau de qualité

300

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Clone

MOPC 21, monoclonal

Forme

buffered aqueous solution

Technique(s)

flow cytometry: suitable

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

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Description générale

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. An immunoglobulin has two heavy chains and two light chains connected by a disulfide bond. It is a glycoprotein. IgG is a major class of immunoglobulin. Mouse consists of five immunoglobulin classes- IgM, IgG, IgA, IgD and IgE. Mouse IgG is further divided into five classes- IgG1, IgG2a, IgG2b and IgG3.

Spécificité

IgG1 isotype control antibody is specific for anti-mouse whole serum and anti-mouse IgG1. The product does not react with antisera to mouse IgA, IgM, IgG2a, IgG2b, and IgG3.

Application

IgG1 Isotype Control from murine myeloma has been used in:
extracellular DNA fluorescence assay
  • reactive oxygen species (ROS) production analysis
  • immunohistochemistry
  • double labelling immunohistochemistry
  • immunofluorescence
  • flow cytometry
  • immunoprecipitation

IgG1 isotype control antibodies are suitable for use in immunohistochemistry (7μg/ml) and immunoblotting. The product may also be used for flow cytometry.

Actions biochimiques/physiologiques

Immunoglobulin G (IgG) is a glycoprotein antibody that regulates immune responses such as phagocytosis and is also involved in the development of autoimmune diseases . Mouse IgGs have four distinct isotypes, namely, IgG1, IgG2a, IgG2b, and IgG3. IgG1 regulates complement fixation in mice . I
Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It mainly helps in immune defense. IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Lingyun Chen et al.
Journal of agricultural and food chemistry, 54(15), 5577-5582 (2006-07-20)
Parvalbumin is a calcium-binding muscle protein that is highly conserved across fish species and amphibians. It is the major cross-reactive allergen associated with both fish and frog allergy. We used two-dimensional electrophoretic and immunoblotting techniques to investigate the utility of
Megan S Inkeles et al.
JCI insight, 1(15), e88843-e88843 (2016-10-05)
Transcriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides
The Immunoglobulins: Structure and Function (1998)
The adhesive protein invasin of Yersinia pseudotuberculosis induces neutrophil extracellular traps via beta1 integrins
Gillenius E and Urban CF
Microbes and Infection, 17(5), 327-336 (2015)
Rodrigo Sn Barreto et al.
Journal of tissue engineering, 10, 2041731419867962-2041731419867962 (2019-08-27)
The rich extracellular matrix (ECM) and availability make placenta eligible as alternative biomaterial source. Herein we produced placental mouse scaffolds by decellularization, and structure, composition, and cytocompatibility were evaluated to be considered as a biomaterial. We obtained a cell-free scaffold
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