I119

Indatraline hydrochloride

solid

• Synonyme(s) : (±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride, Lu 19-005
• Formule empirique (notation de Hill): C₁₆H₁₅Cl₂N · HCl
• Numéro CAS: 96850-13-4
• Poids moléculaire : 328.66
• Numéro MDL: MFCD00083178
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277939
• Nomenclature NACRES : NA.77

Propriétés

• Forme: solid
• Niveau de qualité: 100
• Couleur: white
• Solubilité: H₂O: 2 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13
• InChI: 1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1
• Clé InChI: QICQDZXGZOVTEF-MELYUZJYSA-N
• Informations sur le gène: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

Description

Application

Indatraline hydrochloride has been used:

• as a competitive inhibitor of 3H-dopamine ([³H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
• as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
• as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)

Actions biochimiques/physiologiques

Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations légales

Sold with the permission of H. Lundbeck A/S.

Informations sur la sécurité

• Pictogrammes: GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H410
• Conseils de prudence: P273 - P391 - P501
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Gloves