E0656

ER-27319

≥98% (HPLC), solid

• Synonyme(s) : 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate
• Formule empirique (notation de Hill): C₂₀H₂₂N₂O₅
• Numéro CAS: 201010-95-9
• Poids moléculaire : 370.40
• Numéro MDL: MFCD07784502
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724472
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Solubilité: DMSO: 28 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C
• InChI: 1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6)
• Clé InChI: IIELZHYJYZBSGG-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

ER-27319 inhibits Syk activation with an IC₅₀ = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.

Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H312
• Conseils de prudence: P264 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364 - P501
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable