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E1523

Sigma-Aldrich

Anti-ERK5 (big-MAPK, BMK1) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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About This Item

Numéro MDL:
MFCD01633332
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.44

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 97 kDa

Espèces réactives

mouse, human

Technique(s)

microarray: suitable
western blot: 1:8,000 using NIH 3T3 mouse fibroblasts cell extract

Numéro d'accès UniProt

Q13164

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MAPK7(5598)
mouse ... Mapk7(23939)

Description générale

Extracellular signal-regulated kinase 5 (ERK5), also referred to as big-MAP kinase 1 (BMK1), is a protein that belongs to mitogen-activated protein kinases family and is expressed mainly in skeletal muscle, kidney, heart and placenta. ERK5 contains a distinct 400-amino acid C-terminal and loop-12 domain, which includes two proline-rich regions.

Immunogène

synthetic peptide corresponding to amino acids 789-802 of human ERK5.

Application

Anti-ERK5 (big-MAPK, BMK1) an0tibody produced in rabbit has been used in immunoblotting.

Actions biochimiques/physiologiques

Extracellular signal-regulated kinase 5 (ERK5) has a critical role in different cellular processes like differentiation, proliferation and survival. Anti-ERK5 (big-MAPK, BMK1) antibody can be used to study the differential tissue expression and intracellular localization of the MAP Kinase isoform in normal and neoplastic tissues.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000251305
0000234101
029M4864V
104M4779V
112M4842

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Consulter la Bibliothèque de documents

Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth
Abe MK, et al.
Molecular and Cellular Biology, 19(2), 1301-1312 (1999)
An evolutionarily conserved pathway controls proteasome homeostasis
Rousseau A and Bertolotti A
Nature, 536(7615), 184-184 (2016)
Adrien Rousseau et al.
Nature, 536(7615), 184-189 (2016-07-28)
The proteasome is essential for the selective degradation of most cellular proteins, but how cells maintain adequate amounts of proteasome is unclear. Here we show that there is an evolutionarily conserved signalling pathway controlling proteasome homeostasis. Central to this pathway
Y Kato et al.
Nature, 395(6703), 713-716 (1998-10-28)
Epidermal growth factor (EGF) induces cell proliferation in a variety of cell types by binding to a prototype transmembrane tyrosine kinase receptor. Ligation of this receptor by EGF activates Erk1 and Erk2, members of the mitogen-activated protein (MAP) kinase family
Mayur S Parmar et al.
Neurobiology of aging, 35(3), 669-679 (2014-01-15)
Extracellular signal-regulated kinases (ERKs) 1, 2, and 5 have been shown to play distinct roles in proliferation, differentiation, and neuronal viability. In this study, we examined ERK1, 2, and 5 expression and activation in the substantia nigra (SN), striatum (STR)
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