SAB4501984
Anti-NRF2 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
HEBP1, NF-E2 related factor 2, NF2L2, NFE2-related factor 2, NFE2L2
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 67 kDa
Espèces réactives
rat, mouse, human
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... NFE2L2(4780)
Catégories apparentées
Description générale
Anti-NRF2 Antibody detects endogenous levels of total NRF2 protein.
NRF2 (nuclear factor, erythroid 2 like 2) gene is mapped to human chromosome 2q31.2. The encoded protein is localized to dendritic cells. It belongs to the cap ′n′ collar (CNC) family of transcription factors.
Immunogène
The antiserum was produced against synthesized peptide derived from human Nrf2.
Immunogen Range: 556-605
Immunogen Range: 556-605
Application
Anti-NRF2, C-Terminal antibody produced in rabbit has been used in western blotting analysis.
Actions biochimiques/physiologiques
Nrf2 (nuclear factor, erythroid 2 like 2) is involved in the regulation of anti-oxidative and anti-inflammatory response. The protein encoded is a transcription factor that binds to the antioxidant response element of the target gene. In response to oxidative stress, Nrf2 upregulates the enzymes associated with detoxification, anti-inflammation, cytoprotection and antioxidative pathways. Nrf2 affects glucose metabolism and ROS (reactive oxygen species) homeostasis in cancer cells by regulating the pentose phosphate pathway. Thus, Nrf2 is known to contribute to the development of cancer by promoting cell proliferation.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Nrf2 is presented in dendritic cells (DCs) and contributes to the maintenance of redox homeostasis. However, the expression pattern and function of Nrf2 in the maturation of DCs in the glioma-infiltrated microenvironment remain unrevealed. Our study aims to investigate the
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