Accéder au contenu
Merck
Toutes les photos(2)

Key Documents

View All Documentation

C7081

Sigma-Aldrich

WY-14643

Synonyme(s) :

4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Formule empirique (notation de Hill):
C14H14ClN3O2S
Numéro CAS:
50892-23-4
Poids moléculaire :
323.80
Numéro MDL:
MFCD00191335
Code UNSPSC :
12352200
ID de substance PubChem :
24892928
Nomenclature NACRES :
NA.77

Forme

powder

Niveau de qualité

100

Chaîne SMILES 

CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2

InChI

1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)

Clé InChI

SZRPDCCEHVWOJX-UHFFFAOYSA-N

Informations sur le gène

human ... PPARA(5465) , PPARD(5467) , PPARG(5468)
mouse ... Ppara(19013)
rat ... Ppara(25747)

Description générale

WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.

Application

WY-14643 has been used:
  • as a positive control for transfection and luciferase assay
  • to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
  • to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture

Actions biochimiques/physiologiques

Selective PPARα agonist.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H315,H319,H335,H350

Classification des risques

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 6

1 of 6

GW9662 >98% (HPLC)

Sigma-Aldrich

M6191

GW9662

PF-05175157 ≥98% (HPLC)

Sigma-Aldrich

PZ0299

PF-05175157

Mdivi-1 ≥98% (HPLC), powder

Sigma-Aldrich

M0199

Mdivi-1

GW7647 A cell-permeable urea-substituted thioisobutyric acid compound that acts as a potent and selective PPARα.

Sigma-Aldrich

370698

GW7647

GSK3787 ≥98% (HPLC), white to off-white, powder

Sigma-Aldrich

G7423

GSK3787

Fasnall benzenesulfonate salt ≥98% (HPLC)

Sigma-Aldrich

SML1815

Fasnall benzenesulfonate salt

Joe Jongpyo Lim et al.
Drug metabolism and disposition: the biological fate of chemicals, 50(10), 1396-1413 (2021-12-04)
Perfluorinated carboxylic acids (PFCAs) are widespread environmental pollutants for which human exposure has been documented. PFCAs at high doses are known to regulate xenobiotic transporters partly through peroxisome proliferator-activated receptor alpha (PPARα) and constitutive androstane receptor (CAR) in rodent models.
Stefan Clockaerts et al.
Annals of the rheumatic diseases, 71(6), 1012-1018 (2012-02-07)
Infrapatellar fat pad (IPFP) might be involved in osteoarthritis (OA) by production of cytokines. It was hypothesised that production of cytokines is sensitive to environmental conditions. To evaluate cytokine production by IPFP in response to interleukin (IL)1β and investigate the
Vladimir S Shavva et al.
Molecular and cellular biochemistry, 448(1-2), 211-223 (2018-02-15)
Apolipoprotein A-I (ApoA-I) is the main structural and functional protein component of high-density lipoprotein. ApoA-I has been shown to regulate lipid metabolism and inflammation in macrophages. Recently, we found the moderate expression of endogenous apoA-I in human monocytes and macrophages
Ronald Lucarelli et al.
Frontiers in cellular and infection microbiology, 12, 881462-881462 (2022-07-22)
Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation. CYP450 lipid metabolites are anti-inflammatory lipid mediators
WY-14643, a selective agonist of peroxisome proliferator-activated receptor-alpha, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice
Yang R, et al.
Pharmacology, Biochemistry, and Behavior, 153, 97-104 (2017)
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique