F6020

Fenofibrate

≥99% (TLC), powder, lipid regulating drug

• Synonyme(s) : 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
• Formule empirique (notation de Hill): C₂₀H₂₁ClO₄
• Numéro CAS: 49562-28-9
• Poids moléculaire : 360.83
• Numéro CE : 256-376-3
• Numéro MDL: MFCD00133314
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278015
• Nomenclature NACRES : NA.77

Propriétés

• product name: Fenofibrate, ≥99%, powder
• Niveau de qualité: 100
• Pureté: ≥99%
• Forme: powder
• Couleur: off-white
• Auteur: Abbott
• Température de stockage: room temp
• Chaîne SMILES: CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2
• InChI: 1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
• Clé InChI: YMTINGFKWWXKFG-UHFFFAOYSA-N
• Informations sur le gène: human ... PPARA(5465)

Description

Application

Fenofibrate has been used:

• to study its effect on plasma lipids, liver phenotype and gene expression
• to study its impact on endothelium-dependent vasodilatation of thoracic aorta
• to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect

Actions biochimiques/physiologiques

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H373
• Conseils de prudence: P260 - P314 - P501
• Classification des risques: STOT RE 2 Oral
• Organes cibles: Liver
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves