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Merck
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Key Documents

62962

Sigma-Aldrich

L-α-Lysophosphatidylcholine

egg yolk, ≥99.0% (TLC)

Synonyme(s) :

3-sn-Lysophosphatidylcholine, L-α-Lysolecithin

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About This Item

Numéro MDL:
MFCD00131444
Code UNSPSC :
51321705
Nomenclature NACRES :
NA.25

Source biologique

egg yolk

Description

zwitterionic

Pureté

≥99.0% (TLC)

Forme

powder or solid

Composition

16:0, ~69% (fatty acid)
18:0, ~27% (fatty acid)
18:1, ~3% (fatty acid)

Solubilité

chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow

Groupe fonctionnel

phospholipid

Type de lipide

phosphoglycerides

Conditions d'expédition

wet ice

Température de stockage

−20°C

Application


  • The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014).

  • Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).

Actions biochimiques/physiologiques

3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes , inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease .

Autres remarques

Preparation of demembranated frog sperm chromatin

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

Priscila M Hiraiwa et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(7), 727-736 (2018-08-18)
Trypanosomatid parasites are causative agents of neglected human diseases. Their lineage diverged early from the common eukaryotic ancestor, and they evolved singular mechanisms of gene expression that are crucial for their survival. Studies on unusual and essential molecular pathways lead
Nuclear envelope assembly following mitosis.
R Pfaller et al.
Methods in enzymology, 219, 60-72 (1992-01-01)
Fengfeng Lu et al.
Neuroscience bulletin, 35(3), 434-446 (2019-01-27)
The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas
Beibei Duan et al.
Molecules (Basel, Switzerland), 26(6) (2021-04-04)
Fat globule size and phospholipid (PL) content in human milk (HM) were investigated. HM was classified into three groups depending on fat content (A < B < C). PL content (mg/100 g HM) was significantly higher in the C group
Harvey T McMahon et al.
Nature, 438(7068), 590-596 (2005-12-02)
Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization
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