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A8097

Sigma-Aldrich

Acridine Orange hydrochloride solution

>95.0% purity (HPLC), solution

Synonyme(s) :

3,6-Bis(dimethylamino)acridine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C17H19N3 · HCl
Numéro CAS:
65-61-2
Poids moléculaire :
301.81
Numéro Beilstein :
3575587
Numéro MDL:
MFCD00012660
Code UNSPSC :
12171500
ID de substance PubChem :
24891317
Nomenclature NACRES :
NA.47

product name

Acridine Orange hydrochloride solution, 10 mg/mL in H2O, ≥95.0% (HPLC)

Niveau de qualité

200

Pureté

≥95.0% (HPLC)

Forme

solution

Concentration

10 mg/mL in H2O

Technique(s)

microbe id | staining: suitable

Couleur

orange to red

εmax

47-54 at 486-492 nm in water

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

Cl[H].CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C

InChI

1S/C17H19N3.ClH/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14;/h5-11H,1-4H3;1H

Clé InChI

VSTHNGLPHBTRMB-UHFFFAOYSA-N

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Application

Acridine Orange hydrochloride solution has been used to study autophagic cell death. It has also been used for the staining of chromosomes.

Actions biochimiques/physiologiques

Acridine Orange is a metachromatic dye which can stain DNA, RNA and acid glycosaminoglycans. At low concentration it intercalates into DNA and precipitates RNA. However, at high concentration it denatures and precipitates both RNA and DNA. Acridine Orange is also used to analyze autophagy. It goes into acidic organelles in a pH-dependent manner. At neutral pH, acridine orange gives a green fluorescence and in acidic conditions, it accumulates in the acidic organelle giving a bright red fluorescence.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Warning

Mentions de danger

H341

Classification des risques

Muta. 2

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000306280
0000331473
SLCQ6474
0000285461
0000281649

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