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219007

Sigma-Aldrich

Caspase Inhibitor VI

Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.

Synonyme(s) :

Caspase Inhibitor VI, Z-VAD-FMK

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About This Item

Formule empirique (notation de Hill):
C21H28FN3O7
Numéro CAS:
161401-82-7
Poids moléculaire :
453.46
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.54

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
desiccated

Couleur

off-white

Solubilité

DMSO: 9 mg/mL

Conditions d'expédition

ambient

Température de stockage

−20°C

InChI

1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1

Clé InChI

SUUHZYLYARUNIA-YEWWUXTCSA-N

Description générale

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.

Actions biochimiques/physiologiques

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Chiara Brignola et al.
Antioxidants (Basel, Switzerland), 13(7) (2024-07-27)
Despite advancements in therapeutic strategies, the development of drug resistance and metastasis remains a serious concern for the efficacy of chemotherapy against colorectal cancer (CRC). We have previously demonstrated that low expression of ribosomal protein uL3 positively correlates with chemoresistance
Xiaoqing Qian et al.
Journal of cellular physiology, 236(7), 5235-5252 (2020-12-29)
Intratympanic injection of gentamicin has proven to be an effective therapy for intractable vestibular dysfunction. However, most studies to date have focused on the cochlea, so little is known about the distribution and uptake of gentamicin by the counterpart of
Wayne A Cabral et al.
Aging cell, 20(9), e13457-e13457 (2021-08-29)
Hutchinson-Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder most notably characterized by cardiovascular disease and premature death from myocardial infarction or stroke. The majority of cases are caused by a de novo single nucleotide mutation in the LMNA
Takashi Kojima et al.
Disease models & mechanisms, 14(11) (2021-10-09)
KCNQ4 encodes the homotetrameric voltage-dependent potassium ion channel Kv7.4, and is the causative gene for autosomal dominant nonsyndromic sensorineural hearing loss, DFNA2. Dominant-negative inhibition accounts for the observed dominant inheritance of many DFNA2-associated KCNQ4 variants. In addition, haploinsufficiency has been
Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines.
von Hofsten, et al.
Frontiers in Pharmacology, 14, 1141669-1141669 (2023)
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