400010

Caspase-1 Inhibitor I

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonyme(s) : Caspase-1 Inhibitor I, IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
• Formule empirique (notation de Hill): C₂₃H₃₂N₄O₈
• Numéro CAS: 143313-51-3
• Poids moléculaire : 492.52
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 5 mg/mL; water: soluble
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1
• Clé InChI: KQCBPHUOVBKBPQ-SJVNDZIOSA-N

Description

Description générale

A potent, specific, and reversible inhibitor of caspase-1 (K_i = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (K_i = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
caspase-1, human recombinant

Product does not compete with ATP.

Reversible: yes

Target K_i: 200 pM for human recombinant caspase-1

Avertissement

Toxicity: Standard Handling (A)

Séquence

Ac-Tyr-Val-Ala-Asp-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Los, M., et al. 1995. Nature375, 81.
Walker, N.P.C., et al. 1994. Cell78, 343.
Wilson, K.P., et al. 1994. Nature370, 270.
Thornberry, N.A., et al. 1992. Nature356, 768.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable