1.03669

Glycine

granulated, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Synonyme(s) : Acide aminoacétique, Acide aminoéthanoïque, Glycocolle
• Formule linéaire : NH₂CH₂COOH
• Numéro CAS: 56-40-6
• Poids moléculaire : 75.07
• Numéro Beilstein : 635782
• Numéro MDL: MFCD00008131
• Code UNSPSC : 12352209
• Numéro de classement CE : 200-272-2

Propriétés

• Agence: BP; ChP; JP; Ph. Eur.; USP
• Niveau de qualité: 500
• Pression de vapeur: 0.0000171 Pa ( 25 °C)
• Description: granulated EMPROVE^® EXPERT Ph.Eur.,BP,JP,USP
• Gamme de produits: EMPROVE^® EXPERT
• Pureté: 99.0-101.0% (calculated on dried substance, perchloric acid titration)
• Forme: granular
• Technique(s): inhibition assay: suitable
• pH: 5.9-6.4 (20 °C, 50 g/L in H₂O)
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• Pf: 240 °C (dec.) (lit.)
• Densité: 1.161 g/cm³ at 20 °C
• Application(s): liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• Température de stockage: 2-30°C
• Chaîne SMILES: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• Clé InChI: DHMQDGOQFOQNFH-UHFFFAOYSA-N

Description

Description générale

Standard bulk materials often show a tendency for caking, clumping and dust formation which results in laborious weighing processes and manual de-caking processes with a negative impact on manufacturing efficiency. Due to its granulated form, granulated glycine is free-flowing and easy to handle. Its greatly reduced caking behavior facilitates processability, speeds up manufacturing processes and increases operator safety.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Glycine in general is widely used in the biopharma industry as a stabilizer, tonicity modifier, buffer and precipitating agent. It is also used as an emollient, emulsifying agent and solubilizer in solid and semi-solid formulations.
Due to its low microbial and endotoxin limits, Glycine granulated Emprove^® Expert is especially suitable for high-risk applications.

Actions biochimiques/physiologiques

Neurotransmetteur inhibiteur de la moelle épinière, régulateur allostérique des récepteurs du NMDA.

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable