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Key Documents

860512P

Avanti

C12 Ceramide (d18:1/12:0)

Avanti Research - A Croda Brand

Synonyme(s) :

N-lauroyl-D-erythro-sphingosine

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About This Item

Formule empirique (notation de Hill):
C30H59NO3
Numéro CAS:
Poids moléculaire :
481.79
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 10 mg (860512P-10mg)
pkg of 1 × 25 mg (860512P-25mg)
pkg of 1 × 5 mg (860512P-5mg)

Fabricant/nom de marque

Avanti Research - A Croda Brand

Type de lipide

sphingolipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

OC[C@]([H])(NC(CCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C30H59NO3/c1-3-5-7-9-11-13-14-15-16-18-19-21-23-25-29(33)28(27-32)31-30(34)26-24-22-20-17-12-10-8-6-4-2/h23,25,28-29,32-33H,3-22,24,26-27H2,1-2H3,(H,31,34)/b25-23+/t28-,29+/m0/s1

Clé InChI

HXFPPRPLRSPNIB-VARSQMIESA-N

Description générale

C12 Ceramide (d18:1/12:0) is a synthetic ceramide containing sphingosine with lauric acid.

Application

C12 Ceramide (d18:1/12:0) or N-lauroyl-D-erythro-sphingosine has been used:
  • as a lipid standard in the optimization of the liquid chromatography-mass spectrometry (LC-MS) method conditions
  • as an internal standard for lipid extraction in U87MG (human glioma cell line)
  • as an internal standard for the quantification of ceramide using liquid chromatography-mass spectrometry (LC-MS) in rat tissues

Actions biochimiques/physiologiques

Ceramides are signaling sphingolipids, which are implicated in regulating stress responses and inflammation. It also regulates cell growth arrest, differentiation and apoptosis.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860512P-10mg)
5 mL Amber Glass Screw Cap Vial (860512P-25mg)
5 mL Amber Glass Screw Cap Vial (860512P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3


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Consulter la Bibliothèque de documents

Gergely Karsai et al.
The Journal of biological chemistry, 295(7), 1889-1897 (2019-12-22)
Sphingolipids (SLs) are structurally diverse lipids that are defined by the presence of a long-chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB) (mostly d18:1), whereas the dienic LCB sphingadienine (d18:2) contains a second DB at
Ismael González-García et al.
Cell reports, 25(2), 413-423 (2018-10-12)
Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The anorectic effect of E2 is mainly mediated
Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
Mónica Narváez-Rivas et al.
Journal of chromatography. A, 1440, 123-134 (2016-03-02)
The goal of untargeted lipidomics is to have high throughput, yet comprehensive and unambiguous identification and quantification of lipids. Novel stationary phases in LC separation and new mass spectrometric instruments capable of high mass resolving power and faster scanning rate
Sonia Hernández-Tiedra et al.
Autophagy, 12(11), 2213-2229 (2016-11-02)
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main

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