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860052P

Avanti

Ceramide (Brain)

Ceramide (Brain, Porcine), powder

Synonyme(s) :

C18 Ceramide; N-octadecanoyl-D-erythro-sphingosine; N-(octadecanoyl)-sphing-4-enine

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About This Item

Numéro CAS:
497156-25-9
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 200 mg (860052P-200mg)
pkg of 1 × 25 mg (860052P-25mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 860052P

Type de lipide

sphingolipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

InChI

1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1

Clé InChI

VODZWWMEJITOND-NXCSZAMKSA-N

Catégories apparentées

Description générale

Ceramides comprise sphingoid base attached to fatty acyl chain by an amide bond. They vary in length, saturation and hydroxylation of the fatty acid chain and sphingoid base. Ceramides are synthesized by sphingomyelinase in salvage and de novo synthesis pathway. In brain, ceramide synthases mediate the synthesis of ceramides.

Application

Ceramide (Brain) has been used as a lipid standard
  • in ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS)
  • in liquid chromatography with a hydrophilic interaction column
  • in liposome preparation to test it effect on human α–synuclein aggregation

Actions biochimiques/physiologiques

Ceramides are signaling molecules which play a key role in cellular events. Ceramides promote β-amyloid synthesis and induce neuronal death. Ceramide levels are associated with pathogenesis of many disease states. Impairment of ceramide metabolism is implicated in Parkinson′s and Alzheimer′s disease. High levels of ceramide is also associated with depression.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860052P-200mg)
5 mL Amber Glass Screw Cap Vial (860052P-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

James P Madigan et al.
Experimental cell research, 388(2), 111860-111860 (2020-01-24)
There is growing evidence to support a role for the ceramide-metabolizing enzyme, glucosylceramide synthase (GCS), in resistance to a variety of chemotherapeutic agents. Whether GCS contributes to oxaliplatin resistance in colorectal cancer (CRC) has not yet been determined. We have
Ceramide and its related neurochemical networks as targets for some brain disorder therapies
Brodowicz J, et al.
Neurotoxicity Research, 33(2), 474-484 (2018)
Astrocytic ceramide as possible indicator of neuroinflammation
de Wit NM, et al.
Journal of Neuroinflammation, 16(1), 48-48 (2019)
Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APPSL and APPSL/PS1M146L Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?
Barrier L, et al.
International Journal of Alzheimer's Disease, 2011 (2011)
Ceramide function in the brain: when a slight tilt is enough
Mencarelli C and Martinez-Martinez, P
Cellular and Molecular Life Sciences, 70(2), 181-203 (2013)
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