913979

Biotin-Thalidomide

≥95%

• Synonyme(s) : N¹-(4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-N⁵-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide, Biotin-conjugated thalidomide, bio-Thal
• Formule empirique (notation de Hill): C₄₄H₆₄N₈O₁₃S
• Numéro CAS: 2230857-87-9
• Poids moléculaire : 945.09
• Nomenclature NACRES : NA.22

Propriétés

• ligand: thalidomide
• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3OCC(NCCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]4[C@](NC(N5)=O)([H])[C@]5([H])CS4)=O)=O)=O)=O)=O)NC1=O

Description

Application

Biotin-Thalidomide (bio-Thal) is a cereblon affinity probe for PROTAC^® and targeted protein degradation research. Bio-Thal can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required.

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Autres remarques

The dTAG system for immediate and target-specific protein degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable